Genetic Risk Factors for Ischemic and Hemorrhagic Stroke
نویسندگان
چکیده
Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority being multifactorial, with multiple genetic and environmental risk factors of small effect size. Genome-wide association studies and large international consortia have been instrumental in finding genetic risk factors for stroke. While initial studies identified risk loci for specific stroke subtypes, more recent studies also revealed loci associated with all stroke and all ischemic stroke. Risk loci for ischemic stroke and its subtypes have been implicated in atrial fibrillation (PITX2 and ZFHX3), coronary artery disease (ABO, chr9p21, HDAC9, and ALDH2), blood pressure (ALDH2 and HDAC9), pericyte and smooth muscle cell development (FOXF2), coagulation (HABP2), carotid plaque formation (MMP12), and neuro-inflammation (TSPAN2). For hemorrhagic stroke, two loci (APOE and PMF1) have been identified.
منابع مشابه
Association of serum magnesium levels with risk factors, severity and prognosis in ischemic and hemorrhagic stroke patients
Background: Stroke is the third leading cause of mortality worldwide. One of the factors that affect the occurrence of stroke can be attributed to changes in the levels of trace elements. Accumulating evidence has been shown that magnesium, as an important element, is a new predictor of stroke. We aimed to determine the levels of Mg in ischemic stroke patients in comparison with those having th...
متن کاملبررسی اپیدمیولوژیک عوامل خطر اصلی سکته های مغزی در بیماران مراجعه کننده به بیمارستان فرشچیان همدان در سال 1393
Introduction & Objective: Stroke is the third cause of death in developed countries and the most common neurologic disease resulting in disability. Nowadays, several risk factors for stroke are recognized properly. Life style and risk factors such as hypertension and diabetes are different among various cultures and countries. This study was designed to evaluate strokes epidemiology and their c...
متن کاملSafety and feasibility of intravenous thrombolytic therapy in Iranian patients with acute ischemic stroke
Background: Thrombolytic therapy is the only approved treatment for acute cerebral ischemia. The hemorrhagic transformation is the greatest complication of this treatment, which may occur after recanalization of occluded artery. The aim of this study was to determine factors associated with clinical improvement and worsening in patients with acute ischemic stroke treated with intravenous th...
متن کاملبررسی ارتباط سکته مغزی با میزان شاخص توده عضلانی بدن در بیماران بستری شده در بخش نورولوژی بیمارستان سینا همدان در سال 1379
Storke is a disabling neurological disorder and is the third cause of death in the U.S. The various risk factors have been investigated for stroke; the most important of which are age, sex, hypercholesterolemia, smoking, alcoholic dirnks, records of cordiac diseases(specially a trial fibrilation), taking oral contraceptives, takibg some ...
متن کاملIs the serum ferritin level a considerable predictor for hemorrhagic transformation of ischemic stroke?
Background: Hemorrhagic Transformation (HT) of Ischemic Stroke (IS) is a detrimental complication. This study investigated the association between serum ferritin level and HT in patients with massive IS of middle cerebral artery. Methods: Thirty patients with massive IS of middle cerebral artery were enrolled in this prospective cohort study. They were divided into two groups based on...
متن کاملMethylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C.
Hyperhomocysteinemia is an independent risk factor for ischemic stroke. The enzyme methylenetetrahydrofolate reductase (MTHFR) plays a critical role in modulating the levels of plasma homocysteine. Two polymorphisms in the MTHFR gene, C677T, A1298C result in reduced enzyme activity. The mechanisms of ischemic and hemorrhagic stroke are not well understood. Although controversial, previous studi...
متن کامل